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                Levels of anchorage
                to local data and NBD Results     
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                        The table for magnitude
                        shows some results obtained through the
                        different estimates. First note that
                        Murray and Lopez have made substantial
                        revisions between the first GBD estimates
                        published in WDR93 and the GBD96
                        estimates. The GBD96 estimate of DALY
                        loss per 1000 persons are about 20% lower
                        than the WDR93 estimates. In comparison,
                        the difference between GBD96 and COD
                        anchored estimate is marginal, in the
                        range of 0.6 to 2.5%. For YLL and YLD, we
                        do not readily have the rates from WDR93.
                        Comparing GBD96 with COD anchored
                        estimate, we see that YLD rates remain
                        the same. This is to be expected, since
                        both estimates share the same
                        epidemiological inputs and disability
                        weights. The change in YLL rates is
                        between 0 to 3.7%. | 
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                                Magnitude
                                of disease burden in AP, and
                                mortality-disability composition
                                obtained by different estimates. 
                                 | 
                             
                            
                                | Result | 
                                Group | 
                                Minimally
                                Anchored 
                                 | 
                                Intermediately
                                anchored 
                                 | 
                             
                            
                                |   | 
                                  | 
                                WDR93 
                                 | 
                                GBD96 
                                 | 
                                COD 
                                 | 
                                HSV-VAS 
                                 | 
                                HSV-Tor-TTO 
                                 | 
                             
                            
                                | DALY / 1000 | 
                                All | 
                                344 
                                 | 
                                283 
                                 | 
                                277 
                                 | 
                                537 
                                 | 
                                394 
                                 | 
                             
                            
                                |   | 
                                Females | 
                                359 
                                 | 
                                276 
                                 | 
                                269 
                                 | 
                                550 
                                 | 
                                396 
                                 | 
                             
                            
                                |   | 
                                Males | 
                                331 
                                 | 
                                291 
                                 | 
                                293 
                                 | 
                                539 
                                 | 
                                403 
                                 | 
                             
                            
                                | YLL / 1000 | 
                                All | 
                                  | 
                                196 
                                 | 
                                189 
                                 | 
                                189 
                                 | 
                                189 
                                 | 
                             
                            
                                |   | 
                                Females | 
                                  | 
                                185 
                                 | 
                                178 
                                 | 
                                178 
                                 | 
                                178 
                                 | 
                             
                            
                                |   | 
                                Males | 
                                  | 
                                206 
                                 | 
                                206 
                                 | 
                                206 
                                 | 
                                206 
                                 | 
                             
                            
                                | YLD / 1000 | 
                                All | 
                                  | 
                                88 
                                 | 
                                88 
                                 | 
                                348 
                                 | 
                                204 
                                 | 
                             
                            
                                |   | 
                                Females | 
                                  | 
                                90 
                                 | 
                                90 
                                 | 
                                372 
                                 | 
                                217 
                                 | 
                             
                            
                                |   | 
                                Males | 
                                  | 
                                85 
                                 | 
                                87 
                                 | 
                                334 
                                 | 
                                197 
                                 | 
                             
                            
                                | YLL
                                : YLD Ratio | 
                                All | 
                                2.18 
                                 | 
                                2.23 
                                 | 
                                2.15 
                                 | 
                                0.54 
                                 | 
                                0.93 
                                 | 
                             
                            
                                |   | 
                                Females | 
                                2.27 
                                 | 
                                2.06 
                                 | 
                                1.98 
                                 | 
                                0.48 
                                 | 
                                0.82 
                                 | 
                             
                            
                                |   | 
                                Males | 
                                2.10 
                                 | 
                                2.42 
                                 | 
                                2.37 
                                 | 
                                0.62 
                                 | 
                                1.05 
                                 | 
                             
                            
                                | Male :
                                Female Ratio | 
                                DALY | 
                                0.92 
                                 | 
                                1.05 
                                 | 
                                1.09 
                                 | 
                                0.98 
                                 | 
                                1.02 
                                 | 
                             
                            
                                |   | 
                                YLL | 
                                1.11 
                                 | 
                                1.11 
                                 | 
                                1.16 
                                 | 
                                1.16 
                                 | 
                                1.16 
                                 | 
                             
                            
                                |   | 
                                YLD | 
                                0.94 
                                 | 
                                0.94 
                                 | 
                                0.97 
                                 | 
                                0.90 
                                 | 
                                0.91 
                                 | 
                             
                         
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                        Changes in YLL : YLD
                        ratio and Male to Female ratio are
                        minimal between GBD96 and COD anchored
                        estimates. The situation changes
                        completely, however, in case of the
                        HSV-VAS anchored estimates. Recall that
                        the disability weights obtained from the
                        community study in Andhra Pradesh were
                        all higher than the disability weights
                        used in GBD96 study. All projected
                        disability weights based on data from the
                        community survey, are in the range of
                        0.28 to 0.803 with a median value of
                        0.474. Compare this with the GBD96 range
                        of disability weights, which range from 0
                        to 0.85 with a median value of 0.145. As
                        a result the magnitude of HSV anchored
                        disease burden is inflated to nearly
                        twice the COD anchored estimate as well
                        as the GBD96 estimate. The YLL to YLD
                        ratio changes to reflect the higher
                        disability component. Burden due to
                        premature mortality now appears as half
                        of the burden due to disability. The
                        HSV-Torrance-TTO estimates give magnitude
                        of burden intermediate between the COD
                        anchored and HSV-VAS anchored estimates.
                        The reader may recall that the life
                        expectancy at birth in Andhra Pradesh is
                        about 60 years . This is much lower than
                        life expectancy achieved elsewhere in the
                        world. The standard life expectancy used
                        by us is 80 years for males and 82.5
                        years for females. This standard is based
                        on actual experience in some parts of the
                        world. Considering the intermediate
                        mortality level in Andhra Pradesh, the
                        radical shift in relationship of
                        mortality and disability components
                        suggested by the HSV anchored estimates
                        is puzzling. But before we affirm up our
                        views on the HSV estimates, let's
                        continue with the comparison of different
                        estimates, looked at from additional
                        points of view. | 
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                                Age-sex
                                distribution of DALYs from
                                different estimates 
                                 | 
                             
                            
                                | Sex | 
                                Age | 
                                Minimally
                                Anchored 
                                 | 
                                Intermediately
                                anchored 
                                 | 
                             
                            
                                |   | 
                                  | 
                                WDR93 
                                 | 
                                GBD96 
                                 | 
                                Cause of
                                death 
                                 | 
                                HSV-VAS 
                                 | 
                                HSV-Tor-TTO 
                                 | 
                             
                            
                                | Persons | 
                                0-4 | 
                                51.17 
                                 | 
                                35.01 
                                 | 
                                34.14 
                                 | 
                                28.63 
                                 | 
                                30.81 
                                 | 
                             
                            
                                |   | 
                                5-14 | 
                                7.12 
                                 | 
                                11.99 
                                 | 
                                12.59 
                                 | 
                                16.63 
                                 | 
                                15.04 
                                 | 
                             
                            
                                |   | 
                                15-44 | 
                                7.47 
                                 | 
                                30.41 
                                 | 
                                30.40 
                                 | 
                                37.18 
                                 | 
                                34.76 
                                 | 
                             
                            
                                |   | 
                                45-59 | 
                                13.38 
                                 | 
                                11.65 
                                 | 
                                10.76 
                                 | 
                                9.79 
                                 | 
                                10.08 
                                 | 
                             
                            
                                |   | 
                                60+ | 
                                20.85 
                                 | 
                                10.94 
                                 | 
                                12.11 
                                 | 
                                7.78 
                                 | 
                                9.31 
                                 | 
                             
                            
                                | Females | 
                                0-4 | 
                                53.05 
                                 | 
                                34.64 
                                 | 
                                33.89 
                                 | 
                                27.24 
                                 | 
                                29.69 
                                 | 
                             
                            
                                |   | 
                                5-14 | 
                                7.44 
                                 | 
                                10.73 
                                 | 
                                11.40 
                                 | 
                                15.33 
                                 | 
                                13.89 
                                 | 
                             
                            
                                |   | 
                                15-44 | 
                                8.21 
                                 | 
                                33.03 
                                 | 
                                33.16 
                                 | 
                                41.79 
                                 | 
                                38.87 
                                 | 
                             
                            
                                |   | 
                                45-59 | 
                                11.52 
                                 | 
                                10.46 
                                 | 
                                9.56 
                                 | 
                                8.28 
                                 | 
                                8.63 
                                 | 
                             
                            
                                |   | 
                                60+ | 
                                19.78 
                                 | 
                                11.13 
                                 | 
                                11.98 
                                 | 
                                7.36 
                                 | 
                                8.92 
                                 | 
                             
                            
                                | Males | 
                                0-4 | 
                                49.30 
                                 | 
                                35.34 
                                 | 
                                34.37 
                                 | 
                                30.05 
                                 | 
                                31.92 
                                 | 
                             
                            
                                |   | 
                                5-14 | 
                                6.79 
                                 | 
                                13.15 
                                 | 
                                13.68 
                                 | 
                                17.95 
                                 | 
                                16.16 
                                 | 
                             
                            
                                |   | 
                                15-44 | 
                                6.75 
                                 | 
                                27.99 
                                 | 
                                27.87 
                                 | 
                                32.47 
                                 | 
                                30.72 
                                 | 
                             
                            
                                |   | 
                                45-59 | 
                                15.25 
                                 | 
                                12.75 
                                 | 
                                11.86 
                                 | 
                                11.33 
                                 | 
                                11.50 
                                 | 
                             
                            
                                |   | 
                                60+ | 
                                21.91 
                                 | 
                                10.77 
                                 | 
                                12.22 
                                 | 
                                8.20 
                                 | 
                                9.70 
                                 | 
                             
                         
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